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Dihexa was synthesized as a small molecule compound that, in in vitro studies, demonstrated its ability to induce spinogenesis and synaptogenesis at picomolar concentrations

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The rhythmic release of GH secreted by the pituitary gland is controlled by growth hormone-releasing hormone and somatostatin in the hypothalamus ( Regulation of Circadian Clock System on the GH/IGF-1 Axis Human GH (hGH) transgenic mice were used to express the hGH gene in mouse pituitary somatotrophs (Vakili et al., 2016)